A guidance policy for controller performance enhancement utilizing mobile sensor-actuator networks (MSANs) is proposed for a class of distributed parameter systems (DPSs),which are govemed by diffusion partial differential equations (PDEs) with time-dependent spatial domains.Several sufficient conditions for controller performance enhancement are presented.First,the infinite dimensional operator theory is used to derive an abstract evolution equation of the systems under some rational assumptions on the operators,and a static output feedback controller is designed to control the spatial process.Then,based on Lyapunov stability arguments,guidance policies for collocated and non-collocated MSANs are provided to enhance the performance of the proposed controller,which show that the time-dependent characteristic of the spatial domains can significantly affect the design of the mobile scheme.Finally,a simulation example illustrates the effectiveness of the proposed policy.