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分析辽阳市耐药结核病的现状和特点,为制定和完善耐药结核病防控规划提供科学依据。收集辽阳市2015年1月1日~12月31日新登记涂阳肺结核患者痰样本,培养阳性结核分枝杆菌菌株282例,采用比例法对利福平(R)、异烟肼(H)、链霉素(S)、乙胺丁醇(E)、对氨基水杨酸钠(P)5种药物进行药物敏感性试验。采用SPSS 18.0进行统计学分析,率的比较采用χ2检验,P<0.05为差异有统计学意义。结果显示,辽阳市2015年涂阳肺结核患者的总耐药率为26.60%,初治患者耐药率为9.65%,复治患者耐药率为98.15%;总耐多药率为4.96%,初治患者耐多药率为0.44%,复治患者耐多药率为24.07%。辽阳市复治结核病患者耐药结核病疫情较为严重,面临新的问题,需采用更全面的干预措施遏制耐药结核病疫情。
To analyze the current situation and characteristics of drug-resistant TB in Liaoyang and to provide a scientific basis for formulating and improving the prevention and control program of drug-resistant TB. A total of 282 sputum samples of smear positive pulmonary tuberculosis patients were collected from January 1, 2015 to December 31, 2015 in Liaoyang City, and 282 strains of positive Mycobacterium tuberculosis strains were cultured. Ratified (R), isoniazid (H) , Streptomycin (S), ethambutol (E) and sodium p-aminosalicylate (P) were tested for drug susceptibility. SPSS 18.0 was used for statistical analysis, the rate of comparison using χ2 test, P <0.05 for the difference was statistically significant. The results showed that in 2015, the total drug resistance rate of smear-positive pulmonary tuberculosis patients in Liaoyang was 26.60%, that of the untreated patients was 9.65% and that of the retreatment patients was 98.15% and 4.96%, respectively The rate of multidrug-resistant patients was 0.44%, and that of multidrug-resistant patients was 24.07%. Liaoyang City, TuFu TB patients with drug-resistant tuberculosis epidemic is more serious, facing new problems, the need for more comprehensive interventions to curb the epidemic of drug-resistant TB.