近年来常用β肾上腺素阻滞剂(β阻滞剂)预防偏头痛。纳多洛尔和普萘洛尔优于其他β阻滞剂,纳多洛尔又优于普萘洛尔的原因有:(1)普萘洛尔具有高度脂溶性,而纳多洛尔为亲水性,故前者易通过血脑屏障,易得中枢神经系统的副作用,后者则否;(2)服单一剂量普萘洛尔的血浆T_(1/2)短而纳多洛尔的T_(1/2)长,前者每日需服药2次,而后者每日只需服药1次,故推荐用纳多洛尔预防偏头痛。 In recent years, commonly used β-adrenergic blockers (β blockers) to prevent migraine. Nadolol and propranolol are superior to other beta-blockers and nadolol is superior to propranolol for the following reasons: (1) propranolol is highly lipid soluble, and nadolol is Hydrophilic, so the former easily through the blood-brain barrier, easy to get the central nervous system side effects, the latter is not; (2) taking a single dose of propranolol plasma T_ (1/2) short and nadolol T_ (1/2) long, the former need to take 2 times a day, while the latter only need to take medicine 1 times a day, it is recommended to prevent migraine with nadolol.