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15名ANLL患者在诱导化疗前抽取骨髓细胞,在体外分别检测对阿糖胞苷、三尖杉酯碱及6-硫代鸟嘌呤的敏感性,评价白血病祖细胞(L-cFU)的杀伤百分率。同时对正常骨髓进行正常造血祖细胞(cFU-c)的检测,确定出敏感指数(SI)。这15名患者接受由这三种药物组成的HAT方案化疗后,初步结果提示,体外药物敏感性测定与患者对化疗药物的反应有明显的关系。我们认为这一方法对预测疗效是有价值的。
Fifteen patients with ANLL underwent bone marrow cell sampling prior to induction chemotherapy and were tested for sensitivity to cytarabine, harringtonine, and 6-thioguanine in vitro to assess the percentage of L-cFU killing . At the same time normal bone marrow normal hematopoietic progenitor cells (cFU-c) detection, to determine the sensitivity index (SI). The 15 patients undergoing HAT regimen consisting of these three drugs, the preliminary results suggest that the determination of in vitro drug sensitivity and the patient’s response to chemotherapeutic drugs have a clear relationship. We think this method is of value in predicting the efficacy.