Objective This study was undertaken to investigate the influencing factors on serum ALT level and hepatitis C virus(HCV)RNA titer in chronic hepatitis C(CHC)patients.Methods All patients enrolled into this study were anti-HCV positive.Retrospective tracing method was applied to detect serum ALT level and HCV RNA titer and to collect general information of the patients such as genders,age groups,interferon medication history,infection pathways,height and weight.Then the multi-factor analysis was adopted with the application of binominal logistic regression mode.Results The abnormal rate of ALT level was positively correlated to HCV RNA and gender while negatively correlated to interferon medication history and age group,with Wald value of the 4 factors as 39.604,11.823,18.991 and 7.389,respectively.The positive rate of HCV RNA was negatively correlated to interferon medication history and gender while positively correlated to ALT level,with corresponding Wald value of the 3 factors as81.394,7.618 and 27.562,respectively.Conclusions The normal ALT level in HCV infected patients was associated with viral load,age,gender and interferon medication history,while the normal rate of HCV RNA titer was closely associated with gender,interferon medication history and ALT level. Objective This study was undertaken to investigate the influencing factors on serum ALT level and hepatitis C virus (HCV) RNA titer in chronic hepatitis C (CHC) patients. Methods All patients enrolled into this study were anti-HCV positive. Retrospective tracing method was applied to detect serum ALT level and HCV RNA titer and to collect general information of the patient such as genders, age groups, interferon history of treatment, infection pathways, height and weight.Then the multi-factor analysis was adopted with the application of binominal logistic regression mode.Results The abnormal rate of ALT level was positively correlated with HCV RNA and gender while negatively correlated to interferon treatment history and group, with Wald value of the 4 factors as 39.604, 11.823, 18.991 and 7.389, respectively. HCV RNA was negatively correlated to interferon treatment history and gender while positively correlated to ALT level, with corresponding Wald value of the 3 factors as81 .394, 7.618 and 27.562, respectively. Conclusions The normal ALT level in HCV infected patients was associated with viral load, age, gender and interferon medication history, while the normal rate of HCV RNA titer was closely associated with gender, interferon medication history and ALT level.