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目的 为研究角蛋白克隆抗体免疫组化法在检测淋巴结微转移灶上的意义。方法 采用三种角蛋白单克隆抗体AE1,AE3、AE1/AE3,对本院 4 7例大肠癌术后患者 331枚淋巴结用免疫组化法重新检查 ,结果 36枚淋巴结存在微转移灶 ( 11 9% ) ,Duke’sC期患者微转移灶检出率高于Duke’B期患者 (P <0 0 5)。结果 随访显示有微转移灶Duke’sB期病人肿瘤复发 ,远处扩散转移均较无微转移病人高 (P <0 0 5)。结论 作者对大肠癌淋巴结微转移与临床意义进行了讨论
Objective To investigate the significance of immunohistochemical staining of keratin antibody in the detection of lymph node micrometastasis. METHODS: Three keratin monoclonal antibodies AE1, AE3, AE1/AE3 were used to re-examine 331 lymph nodes in 47 patients with colorectal cancer in our hospital by immunohistochemistry. Results 36 micrometastases were found in lymph nodes (11 9 %). The detection rate of micrometastases in Duke’s C stage was higher than that in Duke’B stage (P <0 05). Results Follow-up showed that patients with micrometastasis in Duke’s B stage had tumor recurrence and distant metastases were higher than those without micrometastasis (P < 0.05). Conclusion The authors discussed the clinical significance of lymph node micrometastasis in colorectal cancer