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探讨了四氯化碳性肝硬变大鼠的肾小球的病变,用形态测量法对肾小球的直径和肾小球内细胞的数目进行测量和计数。肾小球内细胞数目随肝硬变的程度和实验动物的生存时间而有变化。通常,肾小球内细胞数目的增加是一过性的,随后,发生细胞数目的减少,肾小球的体积在肝硬变前期没有变化,肝硬变形成后体积开始增大,晚期小肾球体积的增大与肾小球毛细血管基底膜增厚和血管间质的基质的增多有关,电镜下基底膜和基质内有颗粒状电子致密物沉积。用PAP免疫组织化学染色方法显示有深褐色的IgG沉积物。
The glomerular lesions of carbon tetrachloride-induced cirrhosis rats were investigated. The glomerular diameter and the number of cells in the glomerulus were measured and counted by morphometry. The number of cells in the glomerulus varies with the degree of liver cirrhosis and the survival time of experimental animals. In general, the increase in the number of cells in the glomerulus is transient, followed by a reduction in the number of cells, the glomerular volume does not change in the early stage of cirrhosis, and the volume begins to increase after cirrhosis, and late small kidneys The increase in the volume of the ball is related to the thickening of the basement membrane of the glomerular capillaries and the increase of the matrix of the vascular interstitium. Under electron microscopy, granular electron-dense deposits are formed in the basement membrane and stroma. Dark brown IgG deposits were shown with PAP immunohistochemical staining.