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近年来研究显示黑色素瘤转移抑制基因(KiSS-1)及其内源性受体G蛋白偶联受体54(GPR54)是哺乳动物繁殖的开关(gatekeeper),该系统通过促进下丘脑性腺激素释放激素(GnRH)的分泌,发挥其生物学效应。胰脏是动物机体重要的消化器官,分泌多种消化液和激素,对维持动物机体内环境相对稳定具有重要作用。进一步研究发现,在人和小鼠的胰岛中检测到GPR54和Kisspeptin(KiSS-1基因产物)的表达,并且GPR54在胰岛A细胞系和B细胞系中均有表达。适量的Kisspeptin对葡萄糖诱导胰岛B细胞释放胰岛素具有直接作用,但对胰岛A细胞分泌胰高血糖素并无直接影响。本文旨在综述KiSS-1/GPR54系统和胰脏生理作用的关系,为今后研究KiSS-1/GPR54系统在胰脏的作用研究提供理论参考。
In recent years, studies have shown that the melanoma metastasis suppressor gene (KiSS-1) and its endogenous receptor G protein-coupled receptor 54 (GPR54) are mammalian gatekeepers that promote hypothalamic gonadal hormone release Hormone (GnRH) secretion, to exert its biological effects. Pancreas is an important digestive organ of the animal body, the secretion of a variety of digestive juices and hormones, the animal body to maintain a relatively stable environment has an important role. Further studies revealed that expression of GPR54 and Kisspeptin (KiSS-1 gene products) was detected in human and mouse islets, and that GPR54 was expressed in both pancreatic islet A and B cell lines. An appropriate amount of Kisspeptin has a direct effect on glucose-induced islet B cell insulin release, but has no direct effect on pancreatic A-cell secretion of glucagon. The purpose of this article is to review the relationship between the KiSS-1 / GPR54 system and pancreatic physiology and to provide a theoretical reference for the future study of KiSS-1 / GPR54 system in the pancreas.