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目的 测定肺癌患者血浆三种神经多肽的变化。方法 １０３ 例未经治疗的肺癌患者空腹采血，血浆Ｐ物质（ＳＰ） 、生长抑素（ＳＳ） 、血管活性肠肽（ＶＩＰ） 及癌胚抗原（ＣＥＡ） 均采用放免法。结果 肺癌患者ＳＰ、ＳＳ均明显高于正常对照组，而ＶＩＰ明显降低。三型肺癌间ＳＰ、ＶＩＰ及ＳＳ无明显差别。ＶＩＰ与ＳＰ、ＳＳ均呈明显负相关，ＳＰ与ＳＳ呈明显正相关。三种神经多肽与ＣＥＡ 无明显相关性。结论 三种神经多肽的测定有助于肺癌的诊断及免疫功能的研究，但对肺癌分型无明显价值。
Objective To determine the changes of plasma three kinds of neuropeptides in patients with lung cancer. Methods A total of 103 untreated patients with lung cancer underwent fasting blood sampling. Plasma substance P (SP), somatostatin (SS), vasoactive intestinal peptide (VIP) and carcinoembryonic antigen (CEA) were all subjected to radioimmunoassay. Results The SP and SS in lung cancer patients were significantly higher than those in the normal control group, while VIP was significantly lower. There was no significant difference in SP, VIP and SS between the three types of lung cancer. There was a significant negative correlation between VIP and SP and SS. There was a significant positive correlation between SP and SS. There was no significant correlation between the three neuropeptides and CEA. Conclusion The determination of three neuropeptides is helpful for the diagnosis of lung cancer and the study of immune function, but it has no obvious value for the classification of lung cancer.