目的： 探讨血、尿内皮素在慢性肾炎中的作用。方法： 检测正常人、慢性肾小球肾炎患者血内皮素（ＰＥＴ） 和１２ ｈ 尿内皮素排泄量（ＵＥＴ）、内生肌酐清除率（Ｃｃｒ）。结果：所有患者ＰＥＴ、ＵＥＴ水平均升高。ＵＥＴ与病理分级有相关性，ＰＥＴ与病理分级无相关性。结论：内皮素参与慢性肾小球肾炎进展，尿内皮素比血内皮素更能明确反映肾脏病理损害程度且能反映肾小管的损伤程度，是肾小管功能损害的一个指标 Objective: To investigate the role of blood and urine endothelin in chronic nephritis. Methods: The levels of endothelin (ET), urinary endothelin (UET) and endogenous creatinine clearance (Ccr) in normal and chronic glomerulonephritis patients were measured. Results: All patients with PET, UET levels were elevated. There was a correlation between UET and pathological grade, but there was no correlation between PET and pathological grade. CONCLUSION: Endothelin is involved in the progression of chronic glomerulonephritis. Urinary endothelin can reflect renal pathological damage more clearly than blood endothelin and can reflect the degree of renal tubular injury. It is an indicator of renal tubular dysfunction