目的：观察米索前列醇协同缩宫素对预防产后出血的临床疗效并总结护理方法与体会。方法选取我院2008年1月至2013年1月宫产产妇240例，所有产妇均排除以下疾病：肝脏疾病、心脑血管疾病、各类产后出血高危因素、前列醇使用禁忌、凝血机制障。然后随机将产妇分为治疗组和对照组，对照组产妇剖宫产后立即予肌肉缩宫素，治疗组在对照组的基础上，加用米索前列醇片，依次观察两组患者产后出血的发生率、出血量以及子宫收缩的情况。两组均在用药后予综合护理并分析两组护理、治疗效果及不良反应等情况。结果治疗组产后2h及24h出血量及出血发生率明显低于对照组，差异具有统计学意（P<0.01），子宫收缩情况优于对照组(P<0.05)。结论米索前列醇协同缩宫素并给予综合性护理，疗效优于单独缩宫素治疗，可明显减少产后出血量和出血率，不良反应少，安全有效，值得临床推广使用。“,”Objective To observe the synergy oxytocin misoprostol for the prevention of postpartum hemorrhage and summarizes the clinical efficacy of nursing and experience. Methods 240 cases from January 2008 to 2013, al women were excluded from the fol owing diseases: liver disease, cardiovascular disease, various types of risk factors for postpartum hemorrhage, epoprostenol use of taboo, impaired clotting mechanism. Then randomly divided into treatment group and control group,The control group immediately after cesarean section to muscle oxytocin treatment group were based on the addition of misoprostol tablets, fol owed by postpartum were observed the incidence of bleeding, bleeding and uterine contractions situation. After treatment in both groups and analyze two integrated care nursing, therapeutic effects and adverse reactions and so on.Result Treatment group 2h and 24h post-partum bleeding and bleeding rate was significantly lower than the control group, the difference was statistical y significant (P<0.01), uterine contraction than the control group (P<0.05). Conclusion Misoprostol Oxytocin together and give comprehensive care, more effective than oxytocin alone treatment can significantly reduce postpartum bleeding volume and rate of adverse reactions, safe, effective and worthy of clinical use.