分别用国产氨为农(Am)和多巴酚丁胺(Dob)静脉输注治疗30例重度充血性心力衰竭(CHF)患者,对二药的疗效和不良反应进行了比较.结果显示,用药后3天内,二药的疗效无显著差异;用药后4～6天,Am的疗效继续上升,而Dob的疗效则迅速逆转.可能与慢性CHF患者心肌细胞β受体密度下调和机能低下有关.此外,Am还能改善左室舒张功能,降低心肌耗氧量,减少心律失常的发生,因此,对于重度CHF患者,Am优于Dob. Thirty patients with severe congestive heart failure (CHF) were treated with intravenous ammonia (Am) and dobutamine (Dob) intravenously respectively to compare the efficacy and adverse reactions of the two drugs.The results showed that the drug After 3 days, there was no significant difference between the two drugs.After 4 to 6 days, the efficacy of Am continued to rise, while the effect of Dob reversed rapidly, which may be related to the downregulation of β-cell density and hypofunction of cardiomyocytes in chronic CHF patients. In addition, Am can improve left ventricular diastolic function, reduce myocardial oxygen consumption and reduce the incidence of arrhythmia, therefore, for patients with severe CHF, Am better than Dob.