Prealloyed Ti-6Al-4V powders were prepared by electrode induction melting gas atomization (EIGA) and plasma rotating electrode process (PREP) in this work.A comparative study of EIGA and PREP powders for hot isostatic pressing (HIPing) compaction was conducted.Characterization of important technological parameters such as particle size distribution,powder surface morphology and flowability was carried out.Microstructure and mechanical properties of Ti6Al-4V powder compacts HIPed from EIGA and PREP powders were also investigated.The results showed that the EIGA powder has a finer average particle size and higher tap density,while the PREP powder has better flowability and less pores.Micropores can be observed in heat-treated EIGA powder compacts by X-ray tomography and the porosity was found to be about 0.02％.There are no micropores (≥4 μm) to be detected in heat-treated PREP powder compacts.Transgranular fracture mode as well as micropores contributes to the scatter in fatigue property of heat-treated PREP powder compacts.The respective advantages and disadvantages of both EIGA and PREP powders for producing Ti-based complex parts through HIPing were also discussed.