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目的:探讨中药喜炎平注射液治疗儿科急性细菌性肠炎临床研究。方法:选取2012年5月—2013年7月期诊治的急性细菌性肠炎患儿79例,按照随机数字表法将79例患儿随机分为对照组(n=38)与治疗组(n=41)。对照组给予头孢克洛分散片每日25 mg/kg,分3次口服,服用5 d;治疗组给予中药喜炎平注射液0.2~0.4mL/(kg·d)加入静脉滴注100 mL的5%葡萄糖注射液,每日1次,连用5 d。两组其它纠正酸中毒,维持酸碱、水电解质及能量等治疗均相同。比较两组患儿临床疗效、不良反应、便常规及症状改善情况等。两组患儿一般资料之间对比无统计学意义(P>0.05)。结果:治疗组总有效率(92.68%)明显高于对照组(73.69%),且有显著性差异(P<0.05);治疗组发生不良反应患儿3例(7.32%)低于对照组5例(13.15%),但无显著性差异(P>0.05)。结论:中药喜炎平注射液治疗小儿急性细菌性肠炎疗效显著且不良反应较轻,具有重要临床应用价值,值得推广。
Objective: To investigate the clinical research of Xiyanping injection in treating pediatric acute bacterial enteritis. Methods: A total of 79 children with acute bacterial enteritis diagnosed and treated from May 2012 to July 2013 were randomly divided into control group (n = 38) and treatment group (n = 41). The control group was given cefaclor dispersible tablets 25 mg / kg daily for 3 days orally for 5 days. The treatment group was treated with 0.2-0.4 mL / (kg · d) of Xiyanping injection plus 100 mL intravenous drip 5% glucose injection, 1 day, once every 5 d. The other two groups to correct acidosis, maintaining acid-base, water, electrolytes and energy treatment are the same. The clinical efficacy, adverse reactions, routine and symptom improvement in both groups were compared. There was no significant difference between the two groups in general data (P> 0.05). Results: The total effective rate (92.68%) in the treatment group was significantly higher than that in the control group (73.69%) (P <0.05), and 3 cases (7.32%) in the treatment group were less than those in the control group Cases (13.15%), but no significant difference (P> 0.05). Conclusion: Xiyanping injection of traditional Chinese medicine for the treatment of acute bacterial enteritis in children with significant effect and mild adverse reactions, has important clinical value, it is worth promoting.