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应用ＰＣＲ技术检测２０例急性淋巴细胞白血病ＴｃＲγ基因（ＶγＩ，Ｊγ＿（１－２））重排，其扩增产物的长度为４００ｂｐ左右。初治和复发的１３例患儿中有７例检出ＴｃＲγ基因重排，其中复发的３例患儿均有ＴｃＲγ基因重排，完全缓解的７例患儿中有４例检出ＴｃＲγ基因重排，此４例患儿目前继续维持治疗，尚无复发之临床表现。ＴｃＲγ基因重排几乎存在于全部的Ｔ－ＡＬＬ和大部分Ｂ－ＡＬＬ中，其稳定性强。对ＴｃＲγ基因重排的检测可用于协助急淋患儿的诊断及长期监测。进一步研究对指导治疗，判断预后和发病机理的研究有重要意义。
PCR technique was used to detect the rearrangement of TcRγ gene (VγI, Jγ_ (1-2)) in 20 cases of acute lymphoblastic leukemia. The amplified product was about 400bp in length. TcRγ gene rearrangement was detected in 7 out of 13 newly diagnosed and relapsed patients, including 3 cases of recurrent TcRγ gene rearrangement, and 4 of 7 complete remission cases detected TcRγ gene weight Row, the 4 cases of children currently continue to maintain treatment, there is no clinical manifestations of recurrence. TcRγ gene rearrangement is almost stable in all T-ALL and most B-ALL. The detection of TcRγ gene rearrangements can be used to assist in the diagnosis and long-term monitoring of acute lymphocytic children. Further research on the guiding treatment, prognosis and pathogenesis of great significance.