论文部分内容阅读
目的:观察小儿哮喘不同时期的肺功能变化及其临床意义。方法:用MINATO肺功能仪对268例支气管哮喘患儿分别在发作期、缓解期进行肺功能测定(PFT)。对发作期中的46例进行沙丁胺醇吸入支气管扩张实验,缓解期中的66例进行组织胺吸入支气管激发实验。结果:共有182例肺功能异常,分为发作组和缓解组,其中发作组90例,FVC、FEV1、MVV、PEF、V25和V50均明显降低;缓解组92例,MVV、PEF、V25和V50均降低。沙丁胺醇吸入支气管扩张实验46例,其FVC和FEV1均增加≥10%;FEFR均增加≥12%;组织胺吸入支气管激发实验66例。其FEV1均下降20%-30%。结论:小儿哮喘发作期存在大小气道功能障碍,缓解期仍存在小气道功能障碍和气道高反应性。
Objective: To observe the changes of pulmonary function in children with asthma at different periods and its clinical significance. Methods: The pulmonary function tests (PFT) were performed in 268 children with bronchial asthma during the attack and remission periods respectively using MINATO pulmonary function test instrument. 46 patients during the onset of salbutamol inhalation bronchodilation experiments, 66 cases of remission during histamine inhalation bronchial provocation test. Results: A total of 182 cases of pulmonary dysfunction were divided into the attack group and the remission group. Among the 90 patients in the attack group, the FVC, FEV1, MVV, PEF, V25 and V50 were significantly decreased. In the remission group, 92 cases were MVV, PEF, V25 and V50 Are lower. Albuterol inhalation bronchodilation in 46 cases, the FVC and FEV1 were increased ≥ 10%; FEFR were increased ≥ 12%; histamine inhalation bronchial provocation test in 66 cases. Its FEV1 decreased by 20% -30%. Conclusion: There are small and large airway dysfunction during pediatric asthma attack. Small airway dysfunction and airway hyperresponsiveness remain in remission.