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目的探讨脑转移瘤患者放疗后生存状况及影响因素。方法回顾性分析接受放疗的脑转移瘤100例患者资料,通过随访记录患者的生存状况,研究患者的年龄、性别、肿瘤转移数目、病理类型、原发灶控制、Karnofsky体力状况评分(KPS)和血红蛋白水平,并进行单因素和多因素分析。结果治疗4个月后,完全缓解13例,部分缓解65例,无明显变化11例,恶化11例。颅外转移、脑瘤个数、原发性损伤控制情况、KPS评分和血红蛋白水平是影响患者1年生存率的相关因素。颅外转移、脑瘤个数、原发性损伤是否控制、KPS评分是转移瘤患者放疗1年生存率的独立影响因素。结论颅外转移、脑瘤个数、原发性损伤是否控制、KPS评分为脑转移瘤患者放疗后生存状况的影响因素。
Objective To investigate the survival status and influencing factors of patients with brain metastases after radiotherapy. Methods The data of 100 patients with brain metastases undergoing radiotherapy were retrospectively analyzed. The survival status of patients with metastatic brain tumors was retrospectively studied. The age, gender, number of tumor metastases, pathological types, primary tumor control, Karnofsky physical status score (KPS) and Hemoglobin levels, and univariate and multivariate analysis. Results After 4 months of treatment, complete remission in 13 cases, partial remission in 65 cases, no significant change in 11 cases, worsening in 11 cases. Extracranial metastases, number of brain tumors, primary injury control, KPS score and hemoglobin level were the related factors that affected the 1-year survival rate of patients. Extracranial metastases, the number of brain tumors, whether the primary injury is controlled, KPS score is an independent factor affecting the 1-year survival rate of patients with metastases. Conclusion The extracranial metastases, the number of brain tumors and whether the primary injury is controlled or not, KPS score is the influencing factor in the survival of patients with brain metastases after radiotherapy.