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他汀治疗对改善心血管病人预后方面,取得了令人瞩目的成就。除了公认的降胆固醇作用外,研究证据亦表明,他汀具有明确的保护血管内皮细胞、抑制平滑肌细胞增生、抗炎、抗氧化、抑制血小板聚集和稳定斑块等作用。虽然临床中他汀降脂的同时均伴有心血管事件的减少,但仍有部分预后终点改善不能用低密度脂蛋白-胆固醇水平下降所解释,而刚好与他汀调脂外机制的作用吻合。显然,他汀治疗与预后终点改善间存在重要的干预机制,那就是包括他汀调脂在内的抗动脉粥样硬化作用。
Statin treatment has made remarkable achievements in improving the prognosis of cardiovascular patients. In addition to the generally accepted cholesterol-lowering effect, evidence suggests that statins have a clear protective effect on vascular endothelial cells, inhibiting smooth muscle cell proliferation, anti-inflammatory, anti-oxidant, inhibiting platelet aggregation and stabilizing plaque. Although statin lipid lowering is associated with a decrease in cardiovascular events in clinical trials, there is still some improvement in end-point outcomes that can not be explained by a decrease in low-density lipoprotein-cholesterol levels, which coincides with the mechanism of statin lipid-lowering. Obviously, there is an important interventional mechanism between statin therapy and improvement in end-point outcomes, which is anti-atherosclerotic effects including statin lipid regulation.