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神经科学研究表明 ,小脑不仅是维持机体平衡的重要器官 ,更是存贮运动性学习记忆的主要功能脑区。小脑的学习记忆功能主要是通过蒲肯野氏细胞上的AMPA受体的磷酸化作用 ,以小脑突触长时程抑制(LTD)的形式来实现的。小脑蒲氏细胞突触后膜AMPA受体的磷酸化作用是小脑LTD形成过程中各种神经递质传导的共同通路 ,也是LTD形成过程中最为关键的步骤之一。因此 ,AMPA受体是中枢神经系统的突触可塑性变化和小脑学习记忆功能的关键物质。
Neuroscience research shows that the cerebellum is not only an important organ for maintaining body balance, but also a major functional area for storing exercise-learning and memory. The learning and memory function of the cerebellum is mainly achieved through phosphorylation of AMPA receptors on Purkinje cells in the form of cerebellar long-term depression (LTD). The phosphorylation of postsynaptic membrane AMPA receptor in cerebellar Puffy cells is the common pathway of various neurotransmitters during the process of cerebellar LTD formation. It is also one of the most crucial steps in the process of LTD formation. Therefore, AMPA receptors are key substances in synaptic plasticity and cerebellar learning and memory in the central nervous system.