丙烯腈(Acrylonitrile,AN)是一应用广泛的单体。目前对它的急性毒性已有较深入的了解,然而对其慢性毒性还未最后确定。近来,有人提出丙烯腈对人体肝脏有慢性毒性作用,引起了人们的关注。但是在临床上所见到的报道甚少。因此,我们于1983年3月到5月,对从事丙烯腈作业人员进行了血清异柠檬酸脱氢酶(ICDH)活力的测定,以探讨丙烯腈对人体肝脏的慢性毒性。本文就这次测定的资料作一分析和讨论。 Acrylonitrile (AN) is a widely used monomer. At present its acute toxicity has been more in-depth understanding, however, its chronic toxicity has not yet been finalized. Recently, it was suggested that acrylonitrile has a chronic toxic effect on the human liver, a cause for concern. However, few have been reported clinically. Therefore, in March-May 1983, we measured the activity of serum isocitrate dehydrogenase (ICDH) by acrylonitrile practitioners to investigate the chronic toxicity of acrylonitrile to human liver. This paper makes an analysis and discussion on the data of this measurement.