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为探讨调经益母片调经作用的药理作用基础，观察了该药不同剂量组对大鼠血清雌二醇（Ｅ２）子宫平滑肌的影响及其镇痛镇静作用，并与妇坤丸对照。结果：益母片可增加ＳＤ雌性大鼠雌二醇（Ｅ２）的含量，与生理盐水组比较，Ｐ＜０．０５；可增强离体子宫平滑肌的收缩力，与药前比较Ｐ＜０．０１；增强在体子宫平滑肌的收缩强度，与药前比较或与乐氏液对照组比较，Ｐ＜０．０１；提高小鼠对热刺激的痛阈值，与生理盐水组比较，Ｐ＜０．０１；可增加戊巴比妥钠致小鼠睡眠维持时间，与生理盐水组比较，Ｐ＜０．０１。提示调经益母片调经作用可能是提高雌二醇（Ｅ２）的含量，增强子宫平滑肌的收缩强度，镇痛及镇静等作用的体现。
In order to investigate the pharmacological effects of Tiaojingyimu tablet on the role of Tiaojingjing, the effect of different doses of the drug on rat uterus smooth muscle of estradiol (E2) and its analgesic and sedative effects were observed and compared with Fukun Pill. RESULTS: Yimu Tablets could increase the content of estradiol (E2) in SD female rats, compared with saline group, P<0.05; it could enhance the contractility of isolated uterine smooth muscle, compared with that before the drug P<0. 01; enhanced in vivo uterine smooth muscle contraction strength, compared with pre-drug or Lecherhein control group, P <0.01; improve the mouse thermal stimulus pain threshold, compared with the saline group, P <0. 01; can increase the sleep maintenance time of mice caused by pentobarbital sodium, compared with the saline group, P<0.01. It is suggested that the effect of regulating menstruation on the menstruation of Yijing Tablets may be to increase the content of estradiol (E2), enhance the contraction strength of uterine smooth muscle, analgesia and sedation.