低氧下的通气抑制是机体在低氧条件下通气习服中的抑制性因素作用的表现,其机理与中枢内某些抑制性递质的活动有关,本实验用放射免疫测定法、高效液相-电化学测定法、(~3H)2-脱氧葡萄糖结合放射自显影方法、离体脑薄片胞外记录等手段,探讨β-内啡肽,单胺类神经递质对低氧通气抑制的影响,研究低氧通气抑制的中枢定位和通路,实验在去外周化学感受器传入神经、氨基甲酸乙酯麻醉的家兔上以及大鼠和人体上进行.低 Ventilation inhibition under hypoxia is the role of the body’s inhibitory factor in the ventilation habit under hypoxic conditions. The mechanism is related to the activity of certain inhibitory neurotransmitters in the central nervous system. In this experiment, radioimmunoassay, Phase-electrochemical assay, (~ 3H) 2-deoxyglucose combined with autoradiography, and extracellular recording of isolated brain slices were used to investigate the effects of β-endorphin and monoamine neurotransmitter on the inhibition of hypoxia Influence, central location and pathway of hypoxia-induced inhibition, experiments were performed on peripheral chemoreceptor afferent nerves, urethane anesthetized rabbits, and rats and humans.