论文部分内容阅读
目的探讨外源性神经生长因子(NGF)早期干预对重度窒息新生儿脑损伤程度及髓鞘碱性蛋白(MBP)及酸性钙结合蛋白(S-100)的影响。方法共纳入60例重度窒息新生儿患者,采用随机数字法平均分为观察组与对照组,对照组给予常规治疗,观察组在常规基础上给予鼠神经生长因子治疗,观察疗效并行行为神经测定,同时检测MBP及S-100。结果观察组患儿总有效率73.3%明显高于对照组患儿总有效率46.7%;治疗前两组NBNA评分、MBP及S-100比较差异不明显(P>0.05);治疗后NBNA评分均有明显改善,同时治疗后MBP及S-100均明显降低,治疗后不同时间段观察组NBNA评分、MBP及S-100均较对照组改善更明显(P<0.05)。结论早期NGF干预可以更好的降低患儿脑损伤的严重程度,改善患儿的临床症状,同时更好的降低MBP及S-100水平。
Objective To investigate the effects of early intervention with exogenous nerve growth factor (NGF) on the degree of brain injury and the levels of MBP and S-100 in neonates with severe asphyxia. Methods A total of 60 newborns with severe asphyxia were enrolled. The patients were randomly divided into observation group and control group by random number method. The control group was given routine treatment. The observation group was treated with nerve growth factor (NGF) on a routine basis. Simultaneous detection of MBP and S-100. Results The total effective rate in observation group was 73.3%, which was significantly higher than that in control group (46.7%). There was no significant difference in NBNA score, MBP and S-100 between the two groups before treatment (P> 0.05) (P <0.05). Compared with the control group, the NBNA score, MBP and S-100 in the observation group were significantly improved at different time points after treatment. Conclusion Early intervention with NGF can better reduce the severity of brain injury in children, improve the clinical symptoms of children, and better reduce the levels of MBP and S-100.