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目的:探讨无糖尿病的不稳定型心绞痛(UAP)患者血浆胰岛素(INS)样生长因子(IGF)-1与INS抵抗(IR)的关系。方法:42例无糖尿病的UAP患者(UAP组)与30例非冠心病患者(对照组)比较,行75g葡萄糖口服耐量试验,测定空腹、餐后30min、餐后120min血糖、INS、IGF-1水平。结果:UAP组和对照组伴IR患者分别为26例和12例(P<0·05),UAP组中,伴IR与不伴IR者比较,空腹、餐后30min、餐后120minIGF-1明显降低(均P<0·05);HOMA-INS敏感指数(HOMA-ISI)、HOMA-IR指数(HOMA-IRI)分别明显增高和降低(P<0·05)。相关分析显示HOMA-IRI与体质指数(BMI)呈正相关(r=0·353,P<0·05);与空腹及餐后120minIGF-1和IGF-1曲线下面积(IGF-1AUC)呈负相关。多重逐步回归分析显示,HOMA-IRI=0·45722BMI-0·34285IGF-1空腹。结论:IGF-1与无糖尿病的UAP患者IR存在密切关系。
Objective: To investigate the relationship between plasma insulin (INS) -like growth factor (IGF) -1 and insulin resistance (IR) in non-diabetic patients with unstable angina pectoris (UAP). Methods: Forty-two UAP patients without diabetes (UAP group) were compared with 30 non-CHD patients (control group) with oral glucose tolerance test (75g). The fasting, postprandial blood glucose, INS and IGF- Level. Results: UAP group and control group with IR patients were 26 cases and 12 cases (P <0.05), UAP group, with IR and without IR, fasting, postprandial 30min, 120min postprandial IGF-1 significantly (P <0.05). HOMA-ISI and HOMA-IRI were significantly increased and decreased (P <0 · 05), respectively. Correlation analysis showed that there was a positive correlation between HOMA-IRI and body mass index (BMI) (r = 0.353, P <0.05), and negative fasting and post-prandial IGF-1 area Related. Multiple stepwise regression analysis showed that HOMA-IRI = 0 · 45722BMI-0 · 34285IGF-1 fasting. Conclusion: There is a close relationship between IGF-1 and IR in UAP patients without diabetes.