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作者对273名18～25岁的新兵进行白喉类毒素(D)和破伤风类毒素(T)联合制剂(DT)再接种。将受试者随机分成A、B和C3组,分别接种6个絮状反应单位(Lf)T、6LfT+2LfD和6LfT+5LfD。每ml制剂中含1mg Al(OH)_3作为佐剂。接种后1周观察副反应。接种前后4周采集静脉血,用ELISA测定破伤风抗体浓度,用Vero细胞组织培养中和法测定白喉抗体浓度。抗体浓度达0.01IU/ml为保护水平。
The authors recruited 273 recruits aged 18-25 years to diphtheria toxoid (D) and tetanus toxoid (T) combination (DT). Subjects were randomly divided into groups A, B and C3 and inoculated with 6 flocculent reaction units (Lf) T, 6LfT + 2LfD and 6LfT + 5LfD, respectively. Each ml preparation contains 1 mg Al (OH) 3 as an adjuvant. Side effects were observed 1 week after inoculation. Venous blood was collected 4 weeks before and after inoculation, tetanus antibody concentration by ELISA, and diphtheria antibody concentration by Vero cell culture and neutralization method. Antibody concentration of 0.01IU / ml for the protection level.