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目的:探讨河南高发区贲门癌组织浸润淋巴细胞CD4、CD8和δγT的表达变化特征及其意义。方法:采用ABC和组织病理学方法,分析20例贲门癌组织和20例正常贲门对照组淋巴细胞CD4、CD8和δγT的表达状况。结果:贲门癌组织比正常组织CD8(68·05±29·85vs51·85±18·20,P=0·045)和δγT免疫阳性细胞数(7·50±4·24vs4·90±2·65,P=0·025)升高;贲门癌组织CD4免疫阳性细胞数比正常组织降低(68·35±28·73vs89·75±35·34,P=0·042);但是,正常组织CD4+/CD8+细胞比值明显高于贲门癌组织(1·88±0·76vs1·01±0·06,P=0·000)。结论:贲门癌患者免疫功能异常,可能与贲门癌变有关。
Objective: To investigate the characteristics and significance of CD4, CD8 and δγT in infiltrating lymphocytes of gastric cardia in Henan high incidence area. Methods: ABC and histopathological methods were used to analyze the expression of CD4, CD8 and δγT in 20 cases of cardia carcinoma and 20 cases of normal cardia control group. Results: Compared with normal tissues, the positive rate of CD8 (68.05 ± 29.85vs51.85 ± 18.20, P = 0.045) and the number ofδγT immunoreactive cells in cardia cancer tissues (7 · 50 ± 4 · 24vs4 · 90 ± 2.65 , P = 0 · 025). The number of CD4-positive cells in cardia cancer tissues was lower than that in normal tissues (68.35 ± 28.73 vs89.75 ± 35.34, P = 0.402) The ratio of CD8 + cells was significantly higher than that of cardia cancer (1.88 ± 0.76vs1.01 ± 0.06, P = 0.000). Conclusion: Immune dysfunction in patients with cardia cancer may be related to gastric cardia.