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The management of post-stroke complications plays an important role in the quality of life.Di-Tan Decoction (DTD;涤痰汤) is a widely used traditional Chinese medicine.This study incorporated systematic review and meta-analysis to evaluate the efficacy of DTD in post-stroke neurological disorders.Randomized clinical trials (RCTs) were searched from English,Chinese and Korean electronic medical databases,by including the keywords “Di-Tan Tang”,“Di-Tan Decoction”,“Scour Phlegm Decoction”,“stroke”,and “RCT.Each RCT included control (placebo,conventional therapy,or Western medicine) and experimental (DTD treatment) groups.For patients inflicted with stroke for 1-6 weeks,the outcomes of post-stroke neurological disorders were measured by scales for post-stroke symptoms and were classified as ”completely healed“,”markedly effective“,”effective“ and ”ineffective".Totally,11 RCTs (n =490 controls and n =502 DTD subjects) were selected from 210 articles identified in the initial search.A meta-analysis of evaluation criteria in post-stroke symptoms revealed that the overall odds ratio (ORs) for alleviating post-stroke neurological disorders were 0.30-fold lower (95％ CI =0.21-0.43) in the DTD group than the control (Western medicine) group (P ＜ 0.000 01).Moreover,regardless of the type of stroke diagnostic scale applied (including NFA,HDS,and NIHSS),the overall post-stroke symptoms determined were less severe in the DTD group (n =219) than the control group (n =217).No adverse effects of DTD were observed in the 11 RCTs reviewed.All 11 studies used an appropriate method for randomization of subjects to evaluate the risk of bias (ROB),and 7 studies included allocation concealment as well as blinding of patients and practitioners.High-risk ROB was included in 6 RCTs.No significant publication bias was derived from the funnel plot.Our results indicate that the administration of DTD alone,and DTD in combination with Western medicine,exert greater efficacy for post-stroke complication therapy,than Western medicine administered alone.More rigorous and regulated studies are required to confirm the therapeutic efficacy of DTD for post-stroke neurological disorders,disorders.