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目的探讨痰热清联合更昔洛韦治疗呼吸道合胞病毒(RSV)肺炎患儿的临床疗效。方法选取2014年8月至2015年10月湖北省荆州巿妇幼保健院收治的86例RSV肺炎患儿作为研究对象,按照随机数字法将其分为观察组与对照组,各43例。对照组患儿给予痰热清注射液,观察组患儿在对照组基础上静脉滴注更昔洛韦,比较两组患儿治疗效果、临床症状消失时间、复发率及不良反应发生情况。结果观察组患儿治疗的总有效率显著高于对照组,差异有统计学意义(P<0.05);观察组患儿的咳嗽、喘息、痰鸣音以及湿性啰音消失时间均显著短于对照组,差异均有统计学意义(均P<0.05);观察组患儿的复发率显著低于对照组,差异有统计学意义(χ2=7.1492,P<0.05)。结论痰热清联合更昔洛韦治疗RSV肺炎患儿临床效果显著,不仅能快速改善患儿临床症状,且复发率较低,安全有效。
Objective To investigate the clinical efficacy of Tanreqing combined with Ganciclovir in the treatment of children with respiratory syncytial virus (RSV) pneumonia. Methods Eighty-six children with RSV pneumonia admitted from March 2014 to October 2015 in Jingzhou Maternal and Child Health Hospital of Hubei Province were enrolled in this study. According to the random number method, 43 children were divided into observation group and control group. Children in the control group were given Tanreqing injection. The patients in the observation group were given intravenous ganciclovir on the basis of the control group. The treatment effect, the disappearance of clinical symptoms, the recurrence rate and the adverse reactions were compared between the two groups. Results The total effective rate in treatment group was significantly higher than that in control group (P <0.05). The cough, wheezing, phonation and disappearance of wet rales in observation group were significantly shorter than those in control group (All P <0.05). The recurrence rate in the observation group was significantly lower than that in the control group (χ2 = 7.1492, P <0.05). Conclusion Tanreqing combined with ganciclovir treatment of children with RSV pneumonia clinical effect is significant, not only can quickly improve the clinical symptoms of children, and the recurrence rate is low, safe and effective.