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描述了在批式反应器和连续流搅拌反应器 ( CSTR)中酶动力学拆分对映异构体的不同之处。从宏观反应器平衡角度 ,推导出了在 CSTR反应器中不同于在批式反应器中的一定酶立体选择性 ( E)下 ,底物或产物的对映体过量值 ( ees或 eep)与反应的转化率 (ξ)之间关系的定量关系式。并通过商品脂肪酶 ( candidarugosa lipase)及芽孢杆菌 E- 53脂肪酶催化的萘普生甲酯的不对称水解反应得到了证实。分别在批式反应器和 CSTR反应器中进行萘普生的酶法拆分 ,在一定转化率下 ,批式反应器中得到的底物及产物的对映体过量值高于 CSTR反应器中得到的结果。
Describes the differences in enzymatically resolved enantiomers in batch reactors and continuous flow stirred reactors (CSTRs). From the macroscopic reactor balance point of view, the enantiomeric excess (ees or eep) of the substrate or product in the CSTR reactor, different from the enzyme stereoselectivity (E) in the batch reactor and The relationship between the reaction rate (ξ) the quantitative relationship. And the asymmetric hydrolysis of naproxen methyl ester catalyzed by commercial lipase and Bacillus e. 53 lipase was confirmed. Enantioselective resolution of naproxen was carried out in a batch reactor and a CSTR reactor, respectively. At a certain conversion rate, the enantiomeric excess of the substrate and the product obtained in the batch reactor was higher than in the CSTR reactor The results obtained.