多胺(Polyamine)是一类含二个或二个以上胺基的脂肪族化合物。它包括腐胺(Putrescine 1,4-丁二胺)、精脒(Spermidine,1,4,7-庚三胺)、精胺(Spermine,1,3,7,10-癸四胺,亦称精素)及其衍生物。多胺广泛存在于各种动物、植物及细菌体内,是其中某些氨基酸脱羧后的衍生物。早在1677年Leewenhock就发现了精胺。近二、三十年来,不少学者阐明了多胺的生物合成途径,并在深入探讨其生理功能和临床价值。其中比较重要的是,观察到某些微生物的生长确实需要多胺;在生长活跃的动物组织中这些胺类及其合成酶的浓度较高。当细胞由静止期进入生长、分化期时,通常在DNA、RNA及蛋白质合成增高之前,多胺就急剧 Polyamines are a class of aliphatic compounds containing two or more amine groups. It includes putrescine 1,4-butanediamine, spermidine 1,4,7-heptaamine, spermine 1,3,7,10-decanetetramine, also known as Essence) and its derivatives. Polyamines are found in a wide range of animals, plants and bacteria and are derivatives of some of these amino acids after decarboxylation. As early as 1677, Leewenhock discovered spermine. Nearly two or three decades, many scholars have elucidated the polyamine biosynthesis pathway, and in-depth discussion of its physiological function and clinical value. More importantly, it is observed that the growth of certain microorganisms does require polyamines; the concentrations of these amines and their synthases are high in actively growing animal tissues. When cells enter the quiescence from quiescence, the differentiation period, usually in the DNA, RNA and protein synthesis increased, the polyamine on the sharp