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目的 :探讨 c- erb B- 2、VEGF- c、ER、PR在乳腺癌组织中的表达及与临床病理特征之间的关系。方法 :采用PV- 90 0 0二步法分别检测 12 8例乳腺癌、2 5例乳腺良性病变中 c- erb B- 2、VEGF- c、ER、PR的表达。结果 :c- erb B- 2、VEGF- c、ER、PR的表达在乳腺良、恶性病变之间均有显著性差异 (P<0 .0 1) ,c- erb B- 2、VEGF- c的表达与乳腺癌淋巴结转移密切相关 (P<0 .0 1) ;ER、PR与 c- erb B- 2、VEGF- c的表达呈负相关 (P<0 .0 5 ) ;四种蛋白的表达均与乳腺癌发病年龄、肿瘤大小、是否浸润无关 (P>0 .0 5 )。结论 :c- erb B- 2、VEGF- c的过度表达预示着乳腺癌具有较强的转移能力 ,二种蛋白可能在乳腺癌的浸润转移过程中起协同作用。联合检测 c- erb B- 2、VEGF- c、ER、PR对预测乳腺癌的淋巴结转移、判断预后、指导临床治疗具有十分重要的意义。
Objective: To investigate the relationship between the expression of c-erb B- 2, VEGF-c, ER and PR in breast cancer and its clinicopathological characteristics. Methods: The expressions of c-erb B-2, VEGF-c, ER and PR in 125 cases of breast cancer and 25 benign breast lesions were detected by PV-90 0 two-step method. Results: The expressions of c-erb B-2, VEGF-c, ER and PR were significantly different between benign and malignant breast lesions (P <0.01) (P <0.01). The expressions of ER, PR and c-erb B-2 and VEGF-c were negatively correlated (P <0.05). The expressions of four proteins The expression was related to the age of breast cancer, tumor size and infiltration (P> 0.05). CONCLUSION: Overexpression of c-erb B-2 and VEGF-c predicts strong metastatic potential in breast cancer. The two proteins may play a synergistic role in invasion and metastasis of breast cancer. Joint detection of c-erb B-2, VEGF-c, ER, PR in the prediction of lymph node metastasis of breast cancer, to determine the prognosis, to guide the clinical treatment is of great significance.