目前,呼吸系统疾病已经成为中国居民主要死因之一,严重影响病人的工作、生活。肺纤维化是多种肺部病变导致肺泡持续性损伤及细胞外基质的反复破坏,导致肺组织变硬、变厚,肺脏交换氧气进入血液的能力逐步丧失。其临床诊断明确后3年生存率不足50%,5年 At present, respiratory diseases have become one of the major causes of death among Chinese residents, seriously affecting the patient’s work and life. Pulmonary fibrosis is caused by a variety of pulmonary lesions that cause persistent damage to the alveoli and repeated destruction of the extracellular matrix, resulting in hardening and thickening of the lung tissue, and the gradual loss of lung capacity to exchange oxygen into the bloodstream. The clinical diagnosis of 3 years after the survival rate of less than 50%, 5 years