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多层乳剂是很复杂的、不稳定的系统,在其体内及体外稳定性问题未解决之前,很难成为制剂商品。至今如何提高其稳定性的报道尚很少。本文试图使 w/o/w 多层乳剂水相中适当的单体进行聚合,目的是改善乳剂的稳定性,减少多层乳剂破坏的三种主要倾向,即内相水滴的聚结,水滴从油滴中脱出,或油滴聚结。由于制备 w/o/w 乳剂要通过二个步骤,因此,有可能改善任何一个水相(内相或外相),使任一水相通过聚合反应凝胶化。聚丙烯酰胺已被应用于胶凝技术,但作为药用,还需要寻找低毒的胶凝剂。
Multi-layer emulsions are very complex and unstable systems that are difficult to use as a finished product until their in vivo and in vitro stability problems are unresolved. How to improve the stability so far reported very little. This article attempts to polymerize the appropriate monomer in the w / o / w multi-emulsion aqueous phase with the aim of improving the stability of the emulsion and reducing the three major tendencies of multi-emulsion destruction, namely coalescence of in-phase water droplets from Oil droplets prolapse, or coalescence of oil droplets. Since the w / o / w emulsion is passed through two steps, it is possible to improve either aqueous phase (internal phase or external phase), allowing either aqueous phase to gel through the polymerization reaction. Polyacrylamide has been applied to gelation, but as a medicinal, it is also necessary to find a gentler for low toxicity.