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目的探讨磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)、苏氨酸蛋白激酶(serinethreonine kinase,AKT)、第10号染色体缺失的磷酸酶和张力蛋白同源物基因(phosphatase and tensin homolog deleted from chromosome 10,PTEN)在脑胶质瘤中的表达情况及其临床意义。方法本院收治的43例脑胶质瘤患者为观察组,30例其他脑部疾病患者为对照组;根据病理分级分为低级别组23例和高级别组20例;计算各组PI3K、AKT、PTEN表达阳性率。结果观察组PI3K、AKT阳性率显著高于对照组(P<0.05);观察组PTEN阳性率显著低于对照组(P<0.05);低级别组PI3K阳性率和AKT阳性率显著低于高级别组(P<0.05);低级别组PTEN阳性率显著高于高级别组(P<0.05);Pearson相关性分析表明:PI3K与AKT呈显著正相关(r=0.882,P<0.05);PI3K、AKT与PTEN呈显著负相关(r=-0.753,-0.775,P<0.05)。结论 PI3K、AKT、PTEN可相互作用,能够反映脑胶质瘤病情进展。
Objective To investigate the expressions of phosphattidylinositol 3-kinase (PI3K), serine threonine kinase (AKT), phosphatase and tensin homolog deleted from chromosome 10, PTEN) in gliomas and its clinical significance. Methods Forty-three patients with glioma admitted to our hospital were selected as observation group and 30 patients with other brain diseases as control group. According to the pathological grade, 23 cases were divided into low-grade group and 20 cases in high-grade group. PI3K, AKT , PTEN positive expression rate. Results The positive rate of PI3K and AKT in the observation group was significantly higher than that in the control group (P <0.05). The positive rate of PTEN in the observation group was significantly lower than that in the control group (P <0.05). The positive rates of PI3K and AKT in the low-grade group were significantly lower than those in the control group (P <0.05). The positive rate of PTEN in the low-grade group was significantly higher than that in the high-grade group (P <0.05). Pearson correlation analysis showed that there was a significant positive correlation between PI3K and AKT (r = 0.882, There was a significant negative correlation between AKT and PTEN (r = -0.753, -0.775, P <0.05). Conclusions PI3K, AKT and PTEN can interact with each other and reflect the progress of glioma.