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对照研究了鱼肝油酸钠乙醇混合液（ＳＭＰＡ）和无水乙醇（ＰＡＬ）肝癌瘤内局部注射的疗效。其中ＳＭＰＡ组３０个病灶，ＰＡＬ组３２个病灶。结果显示：ＰＡＬ组１例控制不佳，６例原位复发，其中２例原位复发伴门脉癌栓，２例较治疗结束时明显增大。ＳＭＰＡ组均控制良好，随访半至一年半无增大。彩色超声血流成像（ＣＤＦＩ）显示：ＳＭＰＡ较ＰＡＬ快速、完全栓塞肿瘤血管，两组结果有显著性差异（Ｐ值＜０．０５）。病理结果显示：ＳＭＰＡ组浸润区肿瘤细胞绝大部分凝固性坏死，瘤内血管绝大部分栓塞；ＰＡＬ组虽然在浸润中央区肿瘤细胞大部坏死，但在浸润周边区可见血管明显扩张，充血，在肿瘤的包膜上及其周围有较多的增生血管。我们认为：ＳＭＰＡ较ＰＡＬ是一种更为理想的肝癌瘤内局部注射药物。
The efficacy of intratumoral injection of sodium morrhuate ethanol mixture (SMPA) and absolute ethanol (PAL) in hepatocellular carcinoma was studied. There were 30 lesions in the SMPA group and 32 lesions in the PAL group. The results showed that 1 case in the PAL group had poor control and 6 cases relapsed in situ, of which 2 cases had recurrence in situ with portal cancer thrombosis, and 2 cases had a significant increase compared to the end of treatment. The SMPA group had good control and no increase in follow-up from half to a year and a half. Color ultrasound ultrasonography (CDFI) showed that SMPA rapidly and completely embolized tumor vessels compared with PAL. There was a significant difference between the two groups (P<0.05). Pathological results showed that most of the tumor cells in the infiltrating area of the SMPA group had coagulative necrosis, and most of the intratumoral blood vessels were embolized; while in the PAL group, most of the tumor cells in the infiltrating central area were necrotic, the blood vessels in the infiltrating peripheral area were significantly expanded and congested. There are more proliferating blood vessels on and around the tumor’s capsule. We believe that SMPA is a more ideal intratumoral injection of drugs than PAL.