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本文较系统地作了福氏完全佐剂（Ｆｒｅｕｎｄ＇ｓｃｏｍｐｌｅｔｅａｄｊｕｖａｎｔ，ＦＣＡ）包裹５－Ｆｕ的抗肿瘤机理的实验研究。ＦＣＡ包裹５－Ｆｕ相的对包封率平均为：８４．５％。５－Ｆｕ－ＦＣＡ体外缓释试验结果和Ｗｉｓｔａｒ大鼠体内５－Ｆｕ及５－Ｆｕ－ＰＣＡ吸收试验均表明：５－Ｆｕ用ＦＣＡ包裹后，在体内外具有缓慢释放的作用。５０～２００μｇ浓度的５－Ｆｕ在不同作用时间里对肿瘤细胞增殖抑制率随作用时间延长而增加，统计三次实验结果（对Ｈ＿（２２）肝癌细胞），５－Ｆｕ２００μｇ／ｍｌ作用１０分钟对肿瘤细胞增殖抑制率为３４．６６±６．０２；５０μｇ／ｍｌ作用２４小时的抑制率为６１．３５±７．１７。两者比较差别显著（Ｐ＜０．０８）。结果提示：在肿瘤局部低浓度５－Ｆｕ的持续存在，在一定情况下，对肿瘤的抑制作用更强。
This article systematically studied the anti-tumor mechanism of Freund’s complete adjuvant (FCA) encapsulating 5-Fu. The average entrapment efficiency of FCA-wrapped 5-Fu phase is: 84.5%. The results of 5-Fu-FCA sustained-release test in vitro and 5-Fu and 5-Fu-PCA absorption tests in Wistar rats showed that 5-Fu was slowly released in vivo and in vitro after being wrapped with FCA. The concentration of 50-200μg 5-Fu increased the inhibition rate of tumor cells with the prolonged action time. The results of three experiments (for H_(22) hepatoma cells) and 5-Fu 200μg/ml for 10 minutes for tumors The inhibition rate of cell proliferation was 34.66±6.02; the inhibitory effect at 50 μg/ml for 24 hours was 61.35±7.17. There was a significant difference between the two (P<0.08). The results suggest that the persistent presence of low concentrations of 5-Fu in the tumors, under certain conditions, has a stronger inhibitory effect on the tumors.