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目的:~(131)I-碘化油内照射性部分脾切除的可行性。材料与方法:选用杂种犬10只,分治疗组(8只)和对照组(2只),治疗组脾动脉造影后注入不同剂量的~(131)I-碘化油,对照组则仅注入碘化油,术后通过脾动脉造影、SPECT、病理和血生化及肝肾功能变化了解脾大小和形态改变,评价其部分脾切除的可行性。结果:1.术后1-2周肝功能一过性改变,4周恢复正常;血生化及肾功能无异常;2.血管造影见脾动脉分支减少、纤细,脾影缩小;3.SPECT显示脾大小和重量均缩小;4.病理证实脾脏缩小而其他器官未受损害。结论:~(131)I-碘化油介入性核素内照射方法,生物耐受性良好,可以达到部分脾切除的目的,是一种可行的治疗脾亢的新尝试。
Objective: To investigate the feasibility of ~ (131) I-iodized oil internal irradiation partial splenectomy. MATERIALS AND METHODS: Ten hybrid dogs were randomly divided into treatment group (n = 8) and control group (n = 2). The treatment group received 131 I-iodized oil with different doses of splenic arteriography and the control group Iodized oil, postoperative splenic artery angiography, SPECT, pathology and blood biochemistry and liver and kidney function changes understand the spleen size and morphological changes, evaluate the feasibility of partial splenectomy. 1-2 weeks after surgery, a transient change in liver function, 4 weeks returned to normal; no abnormal blood biochemical and renal function; 2 angiography to see the splenic artery branches to reduce, slender, narrow spleen shadow; 3.SPECT display Spleen size and weight are reduced; 4 pathological confirmed that the spleen is reduced while other organs are not damaged. Conclusion: The method of 131I-iodinated oil interventional radionuclide irradiation is well tolerated and can achieve the purpose of partial splenectomy. It is a new attempt to treat hypersplenism.