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用雄性新西兰白兔观察了Ｌ－精氨酸对高脂血症时血浆脂蛋白、血清一氧化氨、脂过氧化物和超氧化物歧化酶的影响。结果发现２％Ｌ－精氨酸与２％胆固醇同时喂养９０天，或喂养９０天以后４％Ｌ－精氨酸治疗９０天，均能有效地抑制高胆固醇所致的血清脂过氧化物的升高，提高高脂血症家兔血清超氧化物歧化酶活性，促进血管内皮细胞一氧化氮的释放。结果提示，Ｌ－精氨酸／一氧化氮可能有抗高脂血症家兔低密度脂蛋白氧化修饰的作用。
Effects of L-arginine on plasma lipoproteins, serum monoamine oxide, lipid peroxides and superoxide dismutase during hyperlipidemia were observed in male New Zealand white rabbits. As a result, it was found that 2% L-arginine and 2% cholesterol were simultaneously fed for 90 days or 4 days after feeding for 90 days and L-arginine treatment for 90 days effectively inhibited the hypercholesterolemia of serum lipid peroxides Increase serum superoxide dismutase activity in rabbits with hyperlipidemia and promote the release of nitric oxide in vascular endothelial cells. The results suggest that L-arginine / nitric oxide may have anti-hyperlipidemic effects of LDL oxidative modification in rabbits.