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分子流行病学是一种新兴的并迅速发展的研究领域。它结合了内剂量、生物有效剂量、生物效应和个体易感性效应等流行病方法学的实验检测方法 ,如接触性生物标记 :尿中的代谢物、DNA加合物、蛋白质加合物和彗星实验参数检测的DNA损伤 ;效应性生物标记 :染色体畸变、姊妹染色单体交换、微核、次黄嘌呤—鸟嘌呤磷酸核糖转移酶基因 (HPRT)的突变 ,编码p5 3或p2 1蛋白的肿瘤基因的活化 ;易感性生物标记 :CYP1A1、GSTM1、GSTT1、NAT2等基因的多态性。但无论什么实验都需要有人类监测的可靠根据。直到现在仍不能解释基因型、接触性生物标记与效应性生物标记之间的关系
Molecular epidemiology is a new and rapidly developing field of research. It combines experimental approaches to epidemiological methods such as internal dosages, bioeffective dosages, biological effects and individual susceptibility effects such as contact biomarkers: urinary metabolites, DNA adducts, protein adducts and comets DNA damage detected by experimental parameters; effect biomarkers: chromosomal aberrations, sister chromatid exchange, micronuclei, mutations in the hypoxanthine-guanine phosphoribosyl transferase gene (HPRT), tumors encoding p5 3 or p2 1 proteins Gene activation; Susceptibility biomarkers: CYP1A1, GSTM1, GSTT1, NAT2 and other genetic polymorphisms. But no matter what the experiment requires a reliable basis for human monitoring. Until now, the relationship between genotypes, contact biomarkers and effector biomarkers still can not be explained