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本文研究淫羊藿总黄酮(FEBM)对家兔血小板功能的影响,结果表明:体外给于FEBM在浓度为1.25～10mg/ml时能显著抑制血小板聚集反应。6.25或12.5mg/ml时可延长凝血酶原时间。FEBM0.1或0.4g/kg每天口服2次连续7次后,对血小板聚集作用、血小板粘附率均无明显影响。说明FEBM抑制血栓形成的作用不是由于对血小板功能的影响。小鼠口服FEBM0.25g/kg·d,连续5天能增强对戊巴比妥钠的镇静催眠作用;口服0.06或0.3g/kg·d,连续11天能延长小鼠游泳时间,具有明显的抗疲劳作用。
This study investigated the effect of total flavonoids of Epimedium (FEBM) on platelet function in rabbits. The results showed that FEBM in vitro can significantly inhibit platelet aggregation at a concentration of 1.25 to 10 mg/ml. Prothrombin time can be prolonged at 6.25 or 12.5 mg/ml. After FEBM 0.1 or 0.4 g/kg twice daily for 7 times, there was no significant effect on platelet aggregation and platelet adhesion rate. The effect of FEBM in inhibiting thrombosis is not due to the effect on platelet function. The oral administration of FEBM at 0.25g/kg·d for 5 days could enhance the sedative and hypnotic effects of pentobarbital sodium. Oral administration of 0.06 or 0.3g/kg·d for 11 days could prolong the swimming time of mice. Anti-fatigue effect.