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血液中可溶性ＭＨＣⅠ类分子具有免疫抑制作用，人工合成ＭＨＣ分子亦具有免疫抑制效果。经大量实验筛选，人工合成相当于ＨＬＡ－７·７５～８４肽能诱受者产生供者特异性免疫耐受，国外正进行临床实验。人工合成ＭＨＣ肽诱导移植免疫耐受机理目前尚不清楚，有研究发现，ＭＨＣ肽能与ＴＣＲ结合，使Ｔ细胞内Ｃａ２＋升高，Ｔ呈无反应性，另有报道ＭＨＣ肽与细胞内ＨＳＰ７０结合形成肽（Ｐ）／ＨＳＰ７０复合物，类似于免疫亲和素一样，抑制细胞内信号传导，阻断ＩＬ－２等的表达。
MHC class I molecules in the blood have immunosuppressive effects and artificially synthesized MHC molecules also have immunosuppressive effects. After a large number of experiments screening, the synthetic equivalent of HLA-7.75 ~ 84 peptide can induce the donor-specific immune tolerance, foreign clinical trials. It is unclear whether synthetic MHC-peptide can induce immune tolerance. Some studies have found that MHC peptide binds to TCR and causes intracellular Ca2 + in T cells to increase. T is non-responsive. It is also reported that MHC peptide binds to intracellular HSP70 Peptide (P) / HSP70 complexes are formed, similar to immunoaffinityins, inhibiting intracellular signaling and blocking the expression of IL-2.