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目的:探讨新生儿溶血病(HDN)血清学检测与其相关影响因素之间的关系。方法:对125例母婴血型不合的新生儿进行ABO溶血病的血清学检测(三项试验),并收集其同期血常规及血清胆红素的检测结果,分析HDN与检测日龄、血红蛋白水平、间胆/总胆比值、性别之间的关系,以及溶血程度与检测日龄、血红蛋白、胆红素水平之间的关系。结果:125例母婴血型不合的病例中,HDN患病85例,阳性率为68.0%。检测日龄与HDN的阳性率、85例阳性组与40例阴性组的血红蛋白水平以及间胆/总胆比值差异均有统计学意义(P<0.05),ABO HDN的发病与性别、ABO HDN溶血程度与日龄、血红蛋白、胆红素的水平差异无统计学意义(P>0.05)。结论:新生儿溶血病血清学检测(三项试验)应作为母婴血型不合的新生儿出生后的常规检测,并结合血红蛋白和胆红素的水平来诊断HDN,并估计其严重程度。
Objective: To investigate the relationship between serological detection of neonatal hemolytic disease (HDN) and related factors. Methods: Serum tests of ABO hemolytic disease were performed in 125 neonates with incompatible maternal and neonates with blood group incompatibility (BPO hemolytic disease). The blood routine and serum bilirubin levels were collected at the same period. HDN, hemoglobin, , The ratio of gallbladder / total gall ratio, gender, and the relationship between hemolysis and the detection of age, hemoglobin, bilirubin levels. Results: Of the 125 cases of maternal-blood incompatibility, 85 cases were HDN-positive, the positive rate was 68.0%. (P <0.05). The incidence and gender of ABO HDN, ABO HDN haemolysis Degree and age, hemoglobin, bilirubin level difference was not statistically significant (P> 0.05). CONCLUSIONS: Hemolytic serodiagnosis (three trials) should be used as a routine measure of postpartum neonates with incompatible maternal and neonates. HDN should be diagnosed based on the level of hemoglobin and bilirubin, and their severity should be estimated.