论文部分内容阅读
乙肝病毒(Hepatitis B virus,HBV)是导致肝脏疾病的主要致病因子,也是导致慢性肝炎、肝硬化、肝癌的最主要原因。亚洲地区位于世界乙肝病毒感染发生的高发区,就中国而言,每年就有近50万人死于因感染HBV导致肝衰、肝硬化、肝癌及并发症,高达57.6%[1-3]。HBV极具特点的复制方式,导致病毒突变发生率高频[4]。HBV DNA包含4个不同区域,每个区域均可发生突变,并且突变所带
Hepatitis B virus (HBV) is the main causative agent of liver disease and the leading cause of chronic hepatitis, cirrhosis and liver cancer. Asia is located in a high incidence of hepatitis B virus infection in the world. As far as China is concerned, nearly half a million people die each year due to infection with HBV and cause up to 57.6% of liver failure, liver cirrhosis, liver cancer and complications [1-3]. HBV replication features very distinctive, leading to high frequency of mutations in the virus [4]. HBV DNA contains four different regions, each region can be mutated, and mutations brought about