类风湿关节炎 (RA)是一种致畸性的自身免疫性疾病 ,发病 2年内即可出现不可逆的骨关节破坏。全世界人口中约有1%的RA患者 ,每年用于医疗及福利的费用达六亿五千万美元[1] ,给患者和社会造成了严重的负担。在过去几十年中 ,对于RA的治疗策略已经从单纯缓解症状过渡到早期干预、? Rheumatoid arthritis (RA) is a teratogenic autoimmune disease that develops irreversible bone and joint destruction within 2 years of onset. About 1% of RA patients in the world’s population spend 650 million U.S. dollars annually on health care and welfare [1], posing a heavy burden on patients and society. Over the past few decades, treatment strategies for RA have shifted from mere symptom relief to early intervention?