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目的了解辽宁省一般人群血中铜、锌水平的分布,并分析其分布特点。方法采用整群随机抽样的方法,于2009—2010年在辽宁省东、中、西部3个城市的区县中,抽取了2 105名6~60岁人群作为调查对象,进行问卷调查及血液样品采集。应用电感耦合等离子体质谱法检测样品中铜、锌水平,分析探讨在不同性别、年龄、地区以及生活方式中铜、锌水平分布情况。结果调查对象血铜几何均数为783μg/L,95%CI为775~791μg/L,P5、P50和P95分别为555、785和1 059μg/L。男性血铜几何均数(778μg/L)低于女性(788μg/L)(P<0.01)。不同年龄组人群血铜几何均数差异有统计学意义(P<0.01),其中6~12岁年龄组血铜最高(为853μg/L),13~16岁年龄组血铜最低(为649μg/L);辽宁省东、中、西部地区人群血铜几何均数分别为706、852和837μg/L,差异有统计学意义(P<0.01);在吸烟与饮酒特征中人群血铜几何均数差异均无统计学意义(P>0.05)。调查对象血锌几何均数为4 158μg/L,95%CI为4 115~4 201μg/L,P5、P50和P95分别为2 657、4 243和5 931μg/L。男性血锌几何均数(4 258μg/L)显著高于女性(4 058μg/L)(P<0.01);不同年龄组人群血锌几何均数差异具有统计学意义(P<0.01),其中,6~12岁年龄组血锌最低(为3 574μg/L),31~45岁年龄组血锌最高(为4 593μg/L);辽宁省东、中、西部地区人群血锌几何均数分别为4 315、3 811和4 286μg/L,差异有统计学意义(P<0.01);吸烟和饮酒人群血锌高于不吸烟、不饮酒人群,差异均有统计学意义(P<0.01)。辽宁省一般人群血铜几何均数(783μg/L)低于全国一般人群血铜(795μg/L)(P<0.01)。辽宁省一般人群血锌几何均数(4 158μg/L)高于全国一般人群血锌(3 996μg/L)(P<0.01)。结论辽宁省一般人群血液中铜、锌水平在不同性别、年龄、区域特征中均存在差异。辽宁省一般人群血铜水平显著低于全国一般人群,而辽宁省血锌水平显著高于全国一般人群水平。
Objective To understand the distribution of copper and zinc levels in the general population in Liaoning Province and to analyze their distribution characteristics. Methods A cluster random sampling method was used to survey 2 1056 ~ 60-year-olds from 2009 to 2010 in three counties in the eastern, central and western Liaoning Provinces for questionnaires and blood samples collection. The contents of copper and zinc in samples were determined by inductively coupled plasma mass spectrometry. The distribution of copper and zinc in different genders, ages, regions and life styles were analyzed. Results The geometric mean of blood copper was 783μg / L, 95% CI was 775 ~ 791μg / L, P5, P50 and P95 were 555,785 and 1 059μg / L, respectively. The geometric mean of blood copper in men (778μg / L) was lower than that in women (788μg / L) (P <0.01). The blood copper geometric mean difference among different age groups was statistically significant (P <0.01), among which the highest blood copper level was 853 μg / L in 6-12 years old group and the lowest was in the 13-16 years old group (649 μg / L). The geometric mean numbers of blood copper in the eastern, central and western regions of Liaoning Province were 706, 852 and 837 μg / L, respectively, with statistical significance (P <0.01) There was no significant difference (P> 0.05). The geometric mean of blood zinc was 4 158 μg / L, 95% CI 4 115-4 420 μg / L, and P 5, P 50 and P 95 were 2 657, 4243 and 5 931 μg / L, respectively. The average geometric mean number of blood zinc in men (4 258 μg / L) was significantly higher than that in female (4 058 μg / L) (P <0.01) The lowest level of blood zinc (3 574 μg / L) was found in the age group of 6 to 12 years and the highest level of blood zinc in the age group of 31 to 45 years (4 593 μg / L). The mean geometric mean number of blood zinc in the eastern, central and western regions of Liaoning Province was 4 315,3 811 and 4 286 μg / L, respectively (P <0.01). The levels of serum zinc in smokers and drinkers were significantly higher than those in nonsmokers and non-drinkers (P <0.01). The average geometric mean of blood copper (783 μg / L) in the general population in Liaoning Province was lower than that of the general population in China (795 μg / L) (P <0.01). The mean geometric mean number of blood zinc (4 158 μg / L) of the general population in Liaoning Province was higher than that of the general population of China (3 996 μg / L) (P 0.01). Conclusion The levels of copper and zinc in the blood of the general population in Liaoning Province are different in different gender, age and regional characteristics. The blood copper level of the general population in Liaoning Province was significantly lower than that of the general population in the country, while the level of blood zinc in Liaoning Province was significantly higher than that of the general population in China.