放射性碘同位素(~(131)I、~(125)I和~(123)I)标记邻碘马尿酸在临床上用于肾功能测定和肾扫描。一般的标记方法是用氧化剂(碘酸盐)在加热加压条件下进行同位素交换来制得。Thakur提出用熔融法标记~(131)I-雌二醇。Westera将此法用于邻碘马尿酸的标记。本文介绍用这种方法标记~(131)I-邻碘马尿酸,反应时间仅需6分钟,标记产率高,不需分离提纯,放化纯度可达99％以上。 Radioiodine isotopes (~ (131) I, ~ (125) I and ~ (123) I) o-iodohippuric acid are clinically used in renal function tests and renal scans. The general labeling method is the use of oxidants (iodate) under the conditions of heat and pressure for isotope exchange. Thakur proposed the fusion method to label ~ (131) I-estradiol. Westera uses this method for o-iodohippuric acid labeling. This article describes the use of this method labeled ~ (131) I-o-iodohippuric acid, the reaction time is only 6 minutes, the labeling yield, without isolation and purification, radiochemical purity of up to 99%.