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目的观察支原体肺炎患儿自身免疫功能的变化,探讨其临床意义。方法选取同期支原体肺炎患儿100例作为观察组,正常患儿100例作为正常对照组,分别检测两组患儿的T细胞亚群、免疫球蛋白、细胞因子如IFN-γ、IL-2、IL-4、IL-6。结果观察组患儿CD4T细胞及CD4/CD8比值降低,主要表现为细胞免疫功能低下,与正常对照组比较,差异有统计学意义(P<0.01);体液免疫功能明显异常,主要表现为IgM,IgA,IgE水平升高,IFN-γ、IL-4、IL-6比对照组明显增高(P<0.05);而IL-2水平比对照组降低,两组间差异有统计学意义(P<0.05)。结论支原体肺炎患儿存在多种自身免疫功能的紊乱,对患儿的自身免疫功能检测可用于本病辅助诊断和监测治疗。
Objective To observe the changes of autoimmune function in children with mycoplasma pneumonia and to explore its clinical significance. Methods 100 children with mycoplasma pneumonia in the same period were selected as the observation group and 100 normal children as the normal control group. T-cell subsets, immunoglobulin, cytokines such as IFN-γ, IL-2, IL-4, IL-6. Results The percentage of CD4 T cells and CD4 / CD8 in the observation group was decreased, which was mainly manifested as cellular immune dysfunction. Compared with the normal control group, the difference was statistically significant (P <0.01); the humoral immune function was abnormal and mainly manifested as IgM, IgA, IgE, IFN-γ, IL-4 and IL-6 were significantly higher than the control group (P <0.05), while IL-2 level was lower than the control group, the difference was statistically significant (P < 0.05). Conclusion There are many autoimmune disorders in children with mycoplasma pneumonia. The detection of autoimmune function in children can be used to diagnose and monitor the disease.