异搏定和地高辛联合应用可以引起血清地高辛浓度升高,这方面还没引起广泛的重视,本文报告两例严重心脏病人,用地高辛治疗中,又加用异搏定控制快速室性心律,此两例均引起血清地高辛浓度明显升高和导致死亡。当地高辛与异搏定联合应用时引起血清地高辛浓度增高,这是与肾脏和肾外对地高辛清除降低有关,肾脏清除降低是由于贤小管排泌功能受抑制,以致中心分布容积减少和半寿期延长。但肝脏降解功能降低的可能性也不能排除。Klein 等认为血清浓度升高很 The combination of verapamil and digoxin can cause elevated concentrations of serum digoxin, this aspect has not aroused widespread attention, this article reports two cases of severe heart disease, with digoxin treatment, plus verapamil rapid control Ventricular arrhythmias, both of which caused a significant increase in serum digoxin concentration and lead to death. Local digoxin and verapamil when used in combination caused by increased concentration of serum digoxin, which is with the kidneys and renal elimination of digoxin on the lower renal clearance reduction is due to Yin tubules excretion suppression, resulting in the central distribution of volume Decrease and half-life extension. However, the possibility of reduced liver function can not be ruled out. Klein so that the serum concentration is very high