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目的:探讨乙型肝炎前S1抗原与乙肝血清标志物(HBV-M)、HBV-DNA检测的实际意义。方法:采用ELISA法检测HBsAg、HBsAb、HBeAg、HBeAb、HBcAb前S1抗原,采用PCR法检测HBV-DNA。结果:292例HBsAg(+)、HBeAg(+)、HBcAb(+)病人组中的前S1抗原阳性率为82.2%,HBV-DNA抗原阳性率为78.1%;134例HBsAg(+)、HBeAb(+)、HBcAb(+)病人组中的前S1抗原阳性率为29.9%,HBV-DNA抗原阳性率为10.4%;160例HBsAg(+)、HBcAb(+)病人组中的前S1抗原阳性率为31.3%,HBV-DNA抗原阳性率为15.6%;9例HBsAg(+)、HBeAg(+)病人组中的前S1抗原阳性率为88.9%,HBV-DNA抗原阳性率为88.9%;52例HBeAb(+)、HBcAb(+)病人组中的前S1抗原阳性率为9.6%,HBV-DNA抗原阳性率为7.7%;结论:前S1抗原与HBV-DNA、HBeAg阳性呈高度正相关,在防治中应引起重视。
Objective: To investigate the practical significance of detection of hepatitis B pre-S1 antigen, hepatitis B serum marker (HBV-M) and HBV-DNA. Methods: Pre-S1 antigens of HBsAg, HBsAb, HBeAg, HBeAb and HBcAb were detected by ELISA. HBV-DNA was detected by PCR. Results: The positive rate of pre-S1 antigen in 292 HBsAg (+), HBeAg (+) and HBcAb (+) patients was 82.2% and the positive rate of HBV DNA antigen was 78.1% +). The positive rate of pre-S1 antigen in HBcAb (+) patients was 29.9% and that of HBV-DNA antigen was 10.4%. The positive rate of pre-S1 antigen in 160 HBsAg (+) and HBcAb Was 31.3%, the positive rate of HBV-DNA antigen was 15.6%. The positive rate of pre-S1 antigen and the positive rate of HBV-DNA antigen were 88.9% and 9 cases of HBsAg (+) and HBeAg (+ The positive rate of pre-S1 antigen in HBeAb (+) and HBcAb (+) patients was 9.6% and the positive rate of HBV-DNA antigen was 7.7% .Conclusion: Pre-S1 antigen was highly positively correlated with HBV-DNA and HBeAg positive Prevention should pay attention.