To quantify the effect of the interaction of non-residual fractions[Fe oxides(Fe), Mn oxide(Mn), organic materials(OMs)] in the surficial sediments and the natural surface coating samples on the adsorption of atrazine(AT), an AT multiple regression adsorption model(AT-MRAM) was developed. The AT-MRAM improves upon the previous AT additional adsorption model(AT-AAM) with superior goodness-of-fit test(adjusted R2=ca.1.000), F-test and t-test(P<0.01), and reveals the effect of the interaction among the components in the surficial sediments(SSs) and na- tural surface coatings samples(NSCSs) on the adsorption of AT, which was neglected by the AT-AAM. Meanwhile, the AT-MRAM was also verified through adsorption experiments of AT and the relative deviation between predicted maximum adsorption of AT and the experimental one is less than 15%. The resulted information shows that Mn is prone to interact with other non-residual components, the total maximum adsorption of AT is inversly proportional to the level of Mn, and Fe and OMs facilitate the adsorption of AT. The results also indicate that the adsorption of AT is not only dominated by Fe, OMs, Fe/OMs, but also restrained by Fe/Mn, Fe/Mn/OMs, with lesser roles attributed to Mn, and the estimated AT distributions among the components do not agree with that previously predicted by the AT-AAM, especially with the relative contribution of Mn to the adsorption of AT, revealing significant contribution of the interactions among non-residual components in controlling the behavior of AT in aquatic environments. To quantify the effect of the interaction of non-residual fractions [Fe oxides (Mn) (Mn), organic materials (OMs)] on the surficial sediments and the natural surface coating samples on the adsorption of atrazine The AT-MRAM improves upon the previous AT additional adsorption model (AT-AAM) with superior goodness-of-fit test (adjusted R2 = ca.1.000), F- test and t-test (P <0.01), and reveals the effect of the interaction among the components in the surficial sediments (SSs) and na- tural surface coatings samples (NSCSs) on the adsorption of AT, which was neglected by the AT -AAM. Meanwhile, the AT-MRAM was also verified through adsorption experiments of AT and the relative deviation between predicted maximum adsorption of AT and the experimental one is less than 15%. The resulted information shows that Mn is likely to interact with other non -residual components, the total maximum adsorption of AT is inversly proportional to the level of Mn, and Fe and OMs facilitate the adsorption of AT. The results also indicate that the adsorption of AT is not only dominated by Fe, OMs, Fe / OMs, but also restrained by Fe / Mn, Fe / Mn / OMs, with lesser roles attributed to Mn, and the estimated AT distributions among the components do not agree with that previously predicted by the AT-AAM, especially with the relative contribution of Mn to the adsorption of AT, revealing significant contributions of the inter- non-residual components in controlling the behavior of AT in aquatic environments.